Back to Search
Start Over
Inhalation and Dermal Uptake of Particle and Gas-Phase Phthalates-A Human Exposure Study
Inhalation and Dermal Uptake of Particle and Gas-Phase Phthalates-A Human Exposure Study
- Source :
- Environmental sciencetechnology. 52(21)
- Publication Year :
- 2018
-
Abstract
- Phthalates are ubiquitous in indoor environments, which raises concern about their endocrine-disrupting properties. However, studies of human uptake from airborne exposure are limited. We studied the inhalation uptake and dermal uptake by air-to-skin transfer with clean clothing as a barrier of two deuterium-labeled airborne phthalates: particle-phase D4-DEHP (di(2-ethylhexyl)phthalate) and gas-phase D4-DEP (diethyl phthalate). Sixteen participants, wearing trousers and long-sleeved shirts, were under controlled conditions exposed to airborne phthalates in four exposure scenarios: dermal uptake alone and combined inhalation + dermal uptake of both phthalates. The results showed an average uptake of D4-DEHP by inhalation of 0.0014 ± 0.00088 (μg kg–1 bw)/(μg m–3)/h. No dermal uptake of D4-DEHP was observed during the 3 h exposure with clean clothing. The deposited dose of D4-DEHP accounted for 26% of the total inhaled D4-DEHP mass. For D4-DEP, the average uptake by inhalation + dermal was 0.0067 ± 0.0045 an...
- Subjects :
- endocrine system
Airborne exposure
030219 obstetrics & reproductive medicine
integumentary system
Inhalation
Chemistry
Skin Absorption
Phthalate
Phthalic Acids
Biological Transport
General Chemistry
010501 environmental sciences
Diethyl phthalate
01 natural sciences
Gas phase
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Human exposure
Research Design
Environmental chemistry
Environmental Chemistry
Humans
0105 earth and related environmental sciences
Skin
Subjects
Details
- ISSN :
- 15205851
- Volume :
- 52
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Environmental sciencetechnology
- Accession number :
- edsair.doi.dedup.....c78a68985da6546052853c4f77d95f7c