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Og4C3 circulating antigen: a marker of infection and adult worm burden in Wuchereria bancrofti filariasis
- Source :
- Europe PubMed Central
-
Abstract
- Og4C3 circulating filarial antigen was detected in the sera of 94.5% (259/274) of microfilaremic patients, 32% (239/751) of persons with presumption of filariasis, and 23% (11/48) of chronic filariasis patients. The antigen level was correlated with the microfilariae (Mf) density and patient age (P < .01). It remained stable in patients treated with microfilaricidal drugs. Og4C3 antigen, undetectable in Mf culture media, was demonstrated to be a rare somatic Mf antigen. It appears to be an excreted or secreted antigen from adult filaria. It could be used as a marker of infection and an indicator of adult worm burden.
- Subjects :
- Male
Adult worm
Helminthiasis
Elephantiasis
Biology
medicine.disease
medicine.disease_cause
Microfilaria
Virology
Filariasis
Infectious Diseases
Wuchereria bancrofti
Elephantiasis, Filarial
Antigen
Antigens, Helminth
parasitic diseases
Immunology
medicine
Immunology and Allergy
Helminths
Animals
Humans
Female
Biomarkers
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Europe PubMed Central
- Accession number :
- edsair.doi.dedup.....c782a461e5437e8bdc4721f1fdee2e04