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Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system

Authors :
Maria Cristina Mele
Marco Cintoni
Antonio Gasbarrini
Emanuele Rinninella
Pauline Raoul
Source :
BioFactors. 48:285-293
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

Vitamin D and its receptor are involved in health and diseases through multiple mechanisms including the immune system and gut microbiota modulations. Gut microbiota variations have huge implications in intestinal and extra-intestinal disorders such as colorectal cancer (CRC). This review highlights the preventive role of vitamin D in colorectal tumorigenesis through the effects on the immune system and gut microbiota modulation. The different associations between vitamin D, gut microbial homeostasis, immune system, and CRC, are dissected. Vitamin D is supposed to exert several chemopreventive effects on CRC including direct antineoplastic mechanisms, the effects on the immune system, and gut microbiota modulation. Large clinical studies with a randomized design, are required to confirm the role of vitamin D in CRC, confirming its key role in the complex interplay between the gut immune system and microbiota.

Details

ISSN :
18728081 and 09516433
Volume :
48
Database :
OpenAIRE
Journal :
BioFactors
Accession number :
edsair.doi.dedup.....c778514a56919653dedd9567f7f78a0b