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Vitamin D and colorectal cancer: Chemopreventive perspectives through the gut microbiota and the immune system
- Source :
- BioFactors. 48:285-293
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Vitamin D and its receptor are involved in health and diseases through multiple mechanisms including the immune system and gut microbiota modulations. Gut microbiota variations have huge implications in intestinal and extra-intestinal disorders such as colorectal cancer (CRC). This review highlights the preventive role of vitamin D in colorectal tumorigenesis through the effects on the immune system and gut microbiota modulation. The different associations between vitamin D, gut microbial homeostasis, immune system, and CRC, are dissected. Vitamin D is supposed to exert several chemopreventive effects on CRC including direct antineoplastic mechanisms, the effects on the immune system, and gut microbiota modulation. Large clinical studies with a randomized design, are required to confirm the role of vitamin D in CRC, confirming its key role in the complex interplay between the gut immune system and microbiota.
- Subjects :
- Colorectal cancer
Clinical Biochemistry
colorectal cancer
vitamin D
Inflammation
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
Gut flora
digestive system
Biochemistry
Colorectal tumorigenesis
Immune system
Vitamin D and neurology
medicine
Humans
Receptor
gut microbiota
biology
Microbiota
General Medicine
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
immune system
inflammation
Immunology
Molecular Medicine
medicine.symptom
Colorectal Neoplasms
Homeostasis
Subjects
Details
- ISSN :
- 18728081 and 09516433
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- BioFactors
- Accession number :
- edsair.doi.dedup.....c778514a56919653dedd9567f7f78a0b
- Full Text :
- https://doi.org/10.1002/biof.1786