Back to Search
Start Over
A Historical Cohort in Kidney Transplantation: 55-Year Follow-Up of 72 HLA-Identical, Donor-Recipient Pairs
- Source :
- Journal of Clinical Medicine; Volume 10; Issue 23; Pages: 5505, Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 10, Iss 5505, p 5505 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- The impact of HLA matching on graft survival has been well characterized in renal transplantation, with a higher degree of matching associated with superior graft survival. Additionally, living donor grafts are known to confer superior survival compared to those from deceased donors. The purpose of this study is to report our multi-decade institutional experience and outcomes for patients who received HLA-identical living donor grafts, which represent the most favorable scenario in kidney transplantation. We conducted a retrospective analysis of these graft recipients performed at a Duke University Medical Center between the years of 1965 and 2002. The recipients demonstrated excellent graft and patient survival outcomes, superior to a contemporary cohort, with median patient and graft survival of 24.2 and 30.9 years, respectively, among Duke recipients vs. 16.1 and 16.0 years in a cohort derived from national data. This study offers a broad perspective on the importance of HLA matching and graft type, and demonstrates a historical best-case-scenario in renal transplantation.
- Subjects :
- kidney transplant
medicine.medical_specialty
business.industry
Patient survival
General Medicine
Human leukocyte antigen
medicine.disease
Living donor
Article
long-term outcomes
HLA matching
precision transplant
Surgery
Transplantation
surgical procedures, operative
Cohort
medicine
Medicine
University medical
business
Kidney transplantation
Historical Cohort
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine; Volume 10; Issue 23; Pages: 5505
- Accession number :
- edsair.doi.dedup.....c760e644dce46014ef5bcd4813dfbb3a
- Full Text :
- https://doi.org/10.3390/jcm10235505