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Expression of multidrug resistance associated transporters (MDR1, MRP1, LRP and BCRP) in porcine oocyte
- Source :
- Scopus-Elsevier
-
Abstract
- Transporters such as P-glycoprotein (MDR1), multidrug resistance protein 1 (MRP1), lung resistance-related protein (LRP) and breast cancer resistance protein (BCRP) are associated with multidrug resistance in various carcinoma cell lines. The expression of these molecules has been also characterized in human normal tissues. However, the expression of these molecules in oocyte is still unclear. In order to obtain more insight into the physiological role of these transporters, their expression in porcine oocyte were examined by reverse transcriptase-polymerase chain reaction. MDR1, MRP1 and LRP genes, but not BCRP gene were found to be expressed in porcine oocyte. After the subcloning and sequence analysis of MDR1, MRP1 and LRP genes, the high homology of these transporters were observed between porcine and human gene. These findings suggest that MDR1, MRP1 and LRP play an important physiological role(s) in an oocyte.
- Subjects :
- Abcg2
Swine
Molecular Sequence Data
Multidrug Resistance Protein 1
Sequence Homology, Nucleic Acid
Genetics
medicine
ATP Binding Cassette Transporter, Subfamily G, Member 2
Animals
Humans
ATP Binding Cassette Transporter, Subfamily B, Member 1
Amino Acid Sequence
Gene
Vault Ribonucleoprotein Particles
Base Sequence
Sequence Homology, Amino Acid
biology
Oncogene
Transporter
General Medicine
Cell cycle
Oocyte
Molecular biology
Drug Resistance, Multiple
Neoplasm Proteins
Subcloning
medicine.anatomical_structure
Gene Expression Regulation
Oocytes
biology.protein
ATP-Binding Cassette Transporters
lipids (amino acids, peptides, and proteins)
Genes, MDR
Multidrug Resistance-Associated Proteins
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....c7549889b881b288b5be4855184fd845