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DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain
- Source :
- Scientific reports 7, 6420 (2017). doi:10.1038/s41598-017-06874-w, Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017), Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Macmillan Publishers Limited, part of Springer Nature, 2017.
-
Abstract
- Scientific reports 7(1), 6420 (2017). doi:10.1038/s41598-017-06874-w<br />Published by Nature Publishing Group, London
- Subjects :
- Protein Folding
Chaperonins
Protein Conformation
Science
Forschungszentren » Zentrum für Medizinische Biotechnologie (ZMB)
Cell Cycle Proteins
Kinases
Protein Serine-Threonine Kinases
Article
Protein Domains
Catalytic Domain
ddc:570
Chaperones
Humans
ddc:610
Phosphorylation
ddc:576
Metabolic Syndrome
Protein-Tyrosine Kinases
Triazoles
Mechanisms of disease
Mutation
Tyrosine
Medicine
Biologie
HeLa Cells
Cell signalling
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scientific reports 7, 6420 (2017). doi:10.1038/s41598-017-06874-w, Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017), Scientific Reports
- Accession number :
- edsair.doi.dedup.....c74e6df3db654f6701e61bc265434ef8
- Full Text :
- https://doi.org/10.1038/s41598-017-06874-w