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Impact of aortic valve replacement for severe aortic stenosis on organic and functional mitral regurgitation
- Source :
- ESC Heart Failure, ESC Heart Failure, Vol 8, Iss 6, Pp 5482-5492 (2021)
- Publication Year :
- 2021
- Publisher :
- John Wiley and Sons Inc., 2021.
-
Abstract
- Aims Concurrent mitral regurgitation (MR) influences treatment considerations in patients with severe aortic stenosis (sAS). Limited information exists regarding haemodynamic effects of sAS on MR severity and outcome of these patients. We assessed the impact of aortic valve replacement (AVR) on MR according to mechanism in patients with sAS and MR. Methods and results In patients with sAS who received surgical or transcatheter AVR from 2008 to 2017, those with effective mitral regurgitant orifice area (ERO) ≥ 10 mm2 prior to AVR were evaluated. The change in MR after AVR was considered significant when there was at least one grade difference. We compared the all‐cause mortality of patients with and without improvement in MR. Of 234 patients with sAS and MR (age 80 ± 9 years, 52% male, ERO 19 ± 7 mm2), organic and functional MR were present in 166 (71%) and 68 (29%), respectively. MR improved in 136 (58%); improvement occurred with similar frequency in organic versus functional MR (59% and 57%, P = 0.88). Associated determinants were absence of atrial fibrillation in organic MR [odds ratio (OR) 2.09, 95% confidence interval (CI) 1.00–4.37; P = 0.049] and indexed aortic valve area (iAVA) ≤ 0.40 cm2 in functional MR (OR 3.28, 95% CI 1.13–9.47; P = 0.028). In the overall cohort, mitral annulus diameter
- Subjects :
- Male
medicine.medical_specialty
Population
Severity of Illness Index
Valve disease
Aortic valve replacement
Internal medicine
medicine
Diseases of the circulatory (Cardiovascular) system
Humans
education
Mitral regurgitation
Aged
Retrospective Studies
Aged, 80 and over
education.field_of_study
business.industry
Aortic stenosis
Hazard ratio
Mitral Valve Insufficiency
Atrial fibrillation
Odds ratio
Original Articles
Aortic Valve Stenosis
medicine.disease
Stenosis
Echocardiography
Heart failure
RC666-701
Aortic Valve
Cardiology
Original Article
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 20555822
- Volume :
- 8
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- ESC Heart Failure
- Accession number :
- edsair.doi.dedup.....c74173ed2c442ce76b20ddb9d4170a6f