Back to Search
Start Over
A Prospective Clinical Study of the Mononucleosis Syndrome in a Developing Country
- Source :
- International Journal of Epidemiology. 9:349-353
- Publication Year :
- 1980
- Publisher :
- Oxford University Press (OUP), 1980.
-
Abstract
- A prospective aetiologic analysis made of 70 children and adults with the clinical and haematologic features of infectious mononucleosis (IM) in Sao Paulo, Brazil, revealed 65.7% due to EBV (31 heterophile antibody positive (HA+), 15 HA negative (HA-) cases), 8.6% due to T. gondii and 4.3% due to CMV. One case was related to viral hepatitis and one to drug hypersensitivity. The other 18.6% were of unknown cause. In the 46 IM cases positive tests were found for EBV/IgM in 93.5%, for heterophile by the absorbed horse Rbc test in 64.2% and by sheep Rbc in 37%. The immune-adherence haemagglutination test was slightly more sensitive than the horse Rbc test in 39 IM sera tested. In 41 EBV/IgM positive sera, EBV/IgA was present in 17/25 containing heterophile antibody and in 2/16 lacking heterophile antibody; anti-EA was present in 85%. The average age of HA+ IM cases was 13.2 years and of HA- cases 4.7 years. Three HA+ and 5 HA- IM cases occurred in the 0-2 year old age group. Few clinical features differentiated between aetiological agents. Exudative tonsillitis was the most helpful one and occurred in 67.7% of HA+ IM cases, 26.7% of HA- cases, in 1 of 3 CMV cases, and not at all in 6 T. gondii infections.
- Subjects :
- Adult
Adolescent
Mononucleosis
Heterophile
Epidemiology
Tonsillitis
Lymphocytosis
Serology
medicine
Humans
Serologic Tests
Infectious Mononucleosis
Prospective Studies
Child
Developing Countries
Hepatitis
biology
business.industry
Infant
Horse
General Medicine
medicine.disease
Immunoglobulin M
Child, Preschool
Cytomegalovirus Infections
Immunology
biology.protein
Viral hepatitis
business
Brazil
Toxoplasmosis
Subjects
Details
- ISSN :
- 14643685 and 03005771
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- International Journal of Epidemiology
- Accession number :
- edsair.doi.dedup.....c740890a08ea7abc1736ec46dfa8e9e3