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Lymph node involvement as the only prognostic factor in curative resected gastric carcinoma: A multivariate analysis
- Source :
- World Journal of Surgery. 13:118-123
- Publication Year :
- 1989
- Publisher :
- Springer Science and Business Media LLC, 1989.
-
Abstract
- The aim of this study was to evaluate the independent influence of clinical and pathological variables on survival of patients with gastric carcinoma using the Cox regression proportional hazard model. Of 156 patients operated on for gastric carcinoma, 46 (29.5%) underwent palliative operation, 24 (15.5%) had a palliative resection, and 86 (55%) had a curative resection. The overall 5-year survival rate was 25 +/- 4%. After curative resection, the 5-year survival rate was 44 +/- 6%. Univariate analysis applied to these patients showed that poor survival was related (p less than 0.01) to: age (over 80 years), absence of epigastric pain, vomiting and dysphagia, total gastrectomy, tumor size (more than 4 cm), lymph node involvement (LNI), invasion through the muscularis propria, absence of intestinal metaplasia near the tumor, and linitis plastica. In multivariate analysis, lymph node involvement was found to be the only independent prognostic factor. The 5-year survival rate was 75.5 +/- 8% without LNI, 28 +/- 10% with proximal LNI, and 7 +/- 6% with distal LNI. Our results suggest that classification into 3 LNI groups is the best staging system for curative resection in gastric carcinoma.
- Subjects :
- Adult
Male
medicine.medical_specialty
Linitis plastica
medicine.medical_treatment
Statistics as Topic
Adenocarcinoma
Gastroenterology
Stomach Neoplasms
Internal medicine
medicine
Humans
Lymph node
Survival rate
Aged
Aged, 80 and over
Univariate analysis
business.industry
Proportional hazards model
Stomach
Carcinoma
Palliative Care
Intestinal metaplasia
Middle Aged
Prognosis
medicine.disease
Surgery
medicine.anatomical_structure
Lymphatic Metastasis
Female
Gastrectomy
business
Subjects
Details
- ISSN :
- 14322323 and 03642313
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- World Journal of Surgery
- Accession number :
- edsair.doi.dedup.....c73faa5bee0bac780e1b68c051600ec0