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Pentose-shunt oxidation in the periosteal cells in healing fractures
- Source :
- Calcified Tissue Research. 23:77-81
- Publication Year :
- 1977
- Publisher :
- Springer Science and Business Media LLC, 1977.
-
Abstract
- The activity of pentose-shunt dehydrogenases is very low in periosteal cells of normal rat metatarsals, but increases one day post-fracture and rises linearly over the next two days. By four days post-fracture, the distribution of this activity along the bone shows two centres of high activity: the first in the region of proliferation to form callus and the second at the site where new bone is first seen, one day later. The high rate of generation of NADPH would be expected to reduce glutathione; reduced glutathione has been shown to inhibit alkaline phosphatase activity in these cells.
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Dehydrogenase
Bone healing
Glucosephosphate Dehydrogenase
Pentose phosphate pathway
Fractures, Bone
chemistry.chemical_compound
Endocrinology
Periosteum
Internal medicine
medicine
Animals
Orthopedics and Sports Medicine
Bony Callus
Wound Healing
Phosphogluconate Dehydrogenase
General Medicine
Glutathione
Alkaline Phosphatase
Rats
Glucose 6-phosphate
chemistry
Callus
Cytochemistry
Alkaline phosphatase
Female
NADP
Subjects
Details
- ISSN :
- 14320827 and 00080594
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Calcified Tissue Research
- Accession number :
- edsair.doi.dedup.....c73ebef8f6f072d900086907c3531e94