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Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old
- Source :
- Nutrients 13(2), 461 (2021). doi:10.3390/nu13020461, Nutrients, Vol 13, Iss 461, p 461 (2021), Nutrients, Volume 13, Issue 2
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Background. Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) may have different effects on cognitive health due to their anti- or pro-inflammatory properties. Methods. We aimed to prospectively examine the relationships between n-3 and n-6 PUFA contents in serum phospholipids with incident all-cause dementia and Alzheimer’s disease dementia (AD). We included 1264 non-demented participants aged 84 ± 3 years from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe) multicenter-cohort study. We investigated whether fatty acid concentrations in serum phospholipids, especially eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), dihomo-γ-linolenic acid (DGLA), and arachidonic acid (AA), were associated with risk of incident all-cause dementia and AD. Results. During the follow-up window of seven years, 233 participants developed dementia. Higher concentrations of EPA were associated with a lower incidence of AD (hazard ratio (HR) 0.76 (95% CI 0.63<br />0.93)). We also observed that higher concentrations of EPA were associated with a decreased risk for all-cause dementia (HR 0.76 (95% CI 0.61<br />0.94)) and AD (HR 0.66 (95% CI 0.51<br />0.85)) among apolipoprotein E ε4 (APOE ε4) non-carriers but not among APOE ε4 carriers. No other fatty acids were significantly associated with AD or dementia. Conclusions. Higher concentrations of EPA were associated with a lower risk of incident AD. This further supports a beneficial role of n-3 PUFAs for cognitive health in old age.
- Subjects :
- Male
eicosapentaenoic acid
epidemiology [Alzheimer Disease]
blood [Fatty Acids, Omega-6]
Alzheimer’s disease dementia
chemistry.chemical_compound
blood [Phospholipids]
0302 clinical medicine
Germany
Activities of Daily Living
030212 general & internal medicine
Longitudinal Studies
Prospective Studies
apolipoprotein E ε4
Phospholipids
chemistry.chemical_classification
Aged, 80 and over
Nutrition and Dietetics
Incidence
Eicosapentaenoic acid
blood [Fatty Acids, Omega-3]
Docosahexaenoic acid
Fatty Acids, Unsaturated
Arachidonic acid
lipids (amino acids, peptides, and proteins)
Female
omega-3
lcsh:Nutrition. Foods and food supply
Polyunsaturated fatty acid
medicine.medical_specialty
blood [Fatty Acids]
Linoleic acid
epidemiology [Germany]
lcsh:TX341-641
epidemiology [Dementia]
fatty acids
Article
03 medical and health sciences
blood [Alzheimer Disease]
Alzheimer Disease
Internal medicine
Fatty Acids, Omega-6
Fatty Acids, Omega-3
medicine
Dementia
Humans
ddc:610
blood [Fatty Acids, Unsaturated]
Proportional Hazards Models
oldest old
business.industry
Fatty acid
medicine.disease
blood [Dementia]
Endocrinology
chemistry
Ageing
blood [Eicosapentaenoic Acid]
dementia
business
030217 neurology & neurosurgery
Food Science
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nutrients 13(2), 461 (2021). doi:10.3390/nu13020461, Nutrients, Vol 13, Iss 461, p 461 (2021), Nutrients, Volume 13, Issue 2
- Accession number :
- edsair.doi.dedup.....c733ed64e5618801a965b3b9b0290822