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COVID-19-related cardiac complications from clinical evidences to basic mechanisms: opinion paper of the ESC Working Group on Cellular Biology of the Heart
- Source :
- Pesce, M, Agostoni, P, Bøtker, H-E, Brundel, B, Davidson, S M, De Caterina, R, Ferdinandy, P, Girao, H, Gyöngyösi, M, Hulot, J-S, Lecour, S, Perrino, C, Schulz, R, Sluijter, J P G, Steffens, S, Tancevski, I, Gollmann-Tepeköylü, C, Tschöpe, C, van Linthout, S & Madonna, R 2021, ' COVID-19 related cardiac complications from clinical evidences to basic mechanisms : Opinion paper of the ESC Working Group on Cellular Biology of the Heart ', Cardiovascular Research, vol. 117, no. 10, pp. 2148-2160 . https://doi.org/10.1093/cvr/cvab201, Cardiovascular Research, Cardiovascular Research, 2021, 117 (10), pp.2148-2160. ⟨10.1093/cvr/cvab201⟩
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- The pandemic of coronavirus disease (COVID)-19 is a global threat, causing high mortality, especially in the elderly. The main symptoms and the primary cause of death are related to interstitial pneumonia. Viral entry also into myocardial cells mainly via the angiotensin converting enzyme type 2 (ACE2) receptor and excessive production of pro-inflammatory cytokines, however, also make the heart susceptible to injury. In addition to the immediate damage caused by the acute inflammatory response, the heart may also suffer from long-term consequences of COVID-19, potentially causing a post-pandemic increase in cardiac complications. Although the main cause of cardiac damage in COVID-19 remains coagulopathy with micro- (and to a lesser extent macro-) vascular occlusion, open questions remain about other possible modalities of cardiac dysfunction, such as direct infection of myocardial cells, effects of cytokines storm, and mechanisms related to enhanced coagulopathy. In this opinion paper, we focus on these lesser appreciated possibilities and propose experimental approaches that could provide a more comprehensive understanding of the cellular and molecular bases of cardiac injury in COVID-19 patients. We first discuss approaches to characterize cardiac damage caused by possible direct viral infection of cardiac cells, followed by formulating hypotheses on how to reproduce and investigate the hyperinflammatory and pro-thrombotic conditions observed in the heart of COVID-19 patients using experimental in vitro systems. Finally, we elaborate on strategies to discover novel pathology biomarkers using omics platforms.
- Subjects :
- 0301 basic medicine
Heart Diseases
Physiology
[SDV]Life Sciences [q-bio]
medicine.medical_treatment
Inflammation
Disease
030204 cardiovascular system & hematology
Bioinformatics
Vascular occlusion
03 medical and health sciences
0302 clinical medicine
Viral entry
Physiology (medical)
medicine
Coagulopathy
Animals
Humans
Myocytes, Cardiac
Blood Coagulation
Cause of death
Myocytes
Ventricular Remodeling
SARS-CoV-2
business.industry
COVID-19
Heart
medicine.disease
Omics
Disease modelling
Infection
Myocardial injury
Biomarkers
Fibrosis
Host-Pathogen Interactions
Inflammation Mediators
[SDV] Life Sciences [q-bio]
030104 developmental biology
Cytokine
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Cardiac
Subjects
Details
- ISSN :
- 17553245 and 00086363
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Research
- Accession number :
- edsair.doi.dedup.....c715ba6bc50d84346615f6092b7532c6