Back to Search
Start Over
Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F2α in wastewater associated with tobacco use
- Source :
- Scientific reports, Scientific Reports, Repositori Universitat Jaume I, Universitat Jaume I, Scientific Reports, 6:39055. Nature Publishing Group, Ryu, Y, Gracia-Lor, E, Bade, R, Baz-Lomba, J A, Bramness, J G, Castiglioni, S, Castrignanò, E, Causanilles, A, Covaci, A, de Voogt, P, Hernandez, F, Kasprzyk-Hordern, B, Kinyua, J, McCall, A-K, Ort, C, Plósz, B G, Ramin, P, Rousis, N I, Reid, M J & Thomas, K V 2016, ' Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F2α in wastewater associated with tobacco use ', Scientific Reports, vol. 6, 39055 . https://doi.org/10.1038/srep39055
- Publication Year :
- 2016
- Publisher :
- Nature Publishing Group, 2016.
-
Abstract
- Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F2-isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F2α (8-iso-PGF2α) was analysed in raw 24 h-composite wastewater samples collected from 4 Norwegian and 7 other European cities in 2014 and 2015. Using the same samples, biomarkers of alcohol (ethyl sulfate) and tobacco (trans-3′-hydroxycotinine) use were also analysed to investigate any possible correlation between 8-iso-PGF2α and the consumption of the two drugs. The estimated per capita daily loads of 8-iso-PGF2α in the 11 cities ranged between 2.5 and 9.9 mg/day/1000 inhabitants with a population-weighted mean of 4.8 mg/day/1000 inhabitants. There were no temporal trends observed in the levels of 8-iso-PGF2α, however, spatial differences were found at the inter-city level correlating to the degree of urbanisation. The 8-iso-PGF2α mass load was found to be strongly associated with that of trans-3′-hydroxycotinine while it showed no correlation with ethyl sulfate. The present study shows the potential for 8-iso-PGF2α as a wastewater biomarker for the assessment of community public health. This work is part of the EU Marie Curie Initial Training Network SEWPROF (Marie Curie-FP7-PEOPLE, grant No. 317205) and the financial support of the EU is greatly acknowledged. E.G.L. is also grateful to Generalitat Valenciana (APOSTD/2015, Programa VALi + d). The authors thank all personnel of the wastewater treatment plants for their collaboration in the collection of the wastewater samples.
- Subjects :
- 0301 basic medicine
population
010501 environmental sciences
Wastewater
medicine.disease_cause
Dinoprost
01 natural sciences
Toxicology
chemistry.chemical_compound
Tobacco Use
Tobacco Use Epidemiology
Cotinine
education.field_of_study
Multidisciplinary
Norway
6. Clean water
SDG 11 - Sustainable Cities and Communities
3. Good health
Multidisciplinary Sciences
Europe
Biomarker (medicine)
patterns of drug use
Regression Analysis
Engineering sciences. Technology
Tobacco use
Population
wastewater analysis
Biology
Sulfuric Acid Esters
Ethyl sulfate
Article
03 medical and health sciences
SDG 3 - Good Health and Well-being
Tobacco
medicine
Humans
Cities
education
0105 earth and related environmental sciences
Urbanization
Oxidative Stress
030104 developmental biology
chemistry
Oxidative stress
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific reports, Scientific Reports, Repositori Universitat Jaume I, Universitat Jaume I, Scientific Reports, 6:39055. Nature Publishing Group, Ryu, Y, Gracia-Lor, E, Bade, R, Baz-Lomba, J A, Bramness, J G, Castiglioni, S, Castrignanò, E, Causanilles, A, Covaci, A, de Voogt, P, Hernandez, F, Kasprzyk-Hordern, B, Kinyua, J, McCall, A-K, Ort, C, Plósz, B G, Ramin, P, Rousis, N I, Reid, M J & Thomas, K V 2016, ' Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F2α in wastewater associated with tobacco use ', Scientific Reports, vol. 6, 39055 . https://doi.org/10.1038/srep39055
- Accession number :
- edsair.doi.dedup.....c70ca6a2f03b20a204de43e47be6f11a