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The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory
- Source :
- Nature Immunology. 16:1034-1043
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Immunological memory is thought to be mediated exclusively by lymphocytes. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection, which suggests the presence of innate immunological memory. Here we identified an important role for the stress-response transcription factor ATF7 in innate immunological memory. ATF7 suppressed a group of genes encoding factors involved in innate immunity in macrophages by recruiting the histone H3K9 dimethyltransferase G9a. Treatment with lipopolysaccharide, which mimics bacterial infection, induced phosphorylation of ATF7 via the kinase p38, which led to the release of ATF7 from chromatin and a decrease in repressive histone H3K9me2 marks. A partially disrupted chromatin structure and increased basal expression of target genes were maintained for long periods, which enhanced resistance to pathogens. ATF7 might therefore be important in controlling memory in cells of the innate immune system.
- Subjects :
- Lipopolysaccharides
Innate immune system
biology
Lipopolysaccharide
Reverse Transcriptase Polymerase Chain Reaction
Kinase
Macrophages
Immunology
Innate lymphoid cell
Activating Transcription Factors
Epigenesis, Genetic
Chromatin
Mice
chemistry.chemical_compound
Histone
chemistry
biology.protein
Animals
Immunology and Allergy
Epigenetics
Immunologic Memory
Transcription factor
Subjects
Details
- ISSN :
- 15292916 and 15292908
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Nature Immunology
- Accession number :
- edsair.doi.dedup.....c704b93a83df387f70f030cea27ec064