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Targeting the Recruitment of Monocytes and Macrophages in Renal Disease
- Source :
- Seminars in Nephrology. 30:318-333
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Macrophages convert proinflammatory or anti-inflammatory signals of tissue microenvironments into response mechanisms. These response mechanisms largely derive from evolutionary conserved defense programs of innate host defense, wound healing, and tissue homeostasis. Hence, in many settings these programs lead to renal inflammation and tissue remodeling (ie, glomerulonephritis and sclerosis or interstitial nephritis and fibrosis). There is abundant experimental evidence that blocking macrophage recruitment or macrophage activation can ameliorate renal inflammation and fibrosis. In this review we discuss experimental tools to target renal macrophage recruitment by using antagonists against selectins, chemokines, integrins, or other important cytokines that mediate renal injury via macrophage recruitment, some of these already having been used in clinical trials.
- Subjects :
- Integrins
Chemokine
Inflammation
Monocytes
Proinflammatory cytokine
Fibrosis
medicine
Animals
Humans
Macrophage
Molecular Targeted Therapy
Tissue homeostasis
Kidney
biology
Macrophages
Dendritic Cells
medicine.disease
medicine.anatomical_structure
Nephrology
Immunology
Selectins
biology.protein
Cytokines
Kidney Diseases
Chemokines
medicine.symptom
Wound healing
Forecasting
Subjects
Details
- ISSN :
- 02709295
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Seminars in Nephrology
- Accession number :
- edsair.doi.dedup.....c7020572c63a9293068dd2f11a95cc95
- Full Text :
- https://doi.org/10.1016/j.semnephrol.2010.03.006