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Synthesis of Azoloquinazolines and Substituted Benzothiazepine as Antimicrobial Agents
- Source :
- Mini reviews in medicinal chemistry. 20(5)
- Publication Year :
- 2018
-
Abstract
- Background & Objective:Quinazolines and their fused systems are noteworthy in pharmaceutical chemistry due to their wide range of biological activities.Methods:A direct and efficient approach for the synthesis of new series of fused quinazolines with triazole, thiazole, benzimidazole and tetrazole has been preceded via the reaction of quinazoline thione derivative with halogenated compounds or cyclocondensation of arylidene of quinazoline derivative with heterocyclic amines. Also, dibenzo[b,e][1,4]thiazepine derivatives was synthesized through the reaction of 2,6-bis-(2-chloro-benzylidene)-cyclohexanone with o-aminothiophenol.Results:The structures of all new synthesized heterocyclic compounds were confirmed and discussed on the bases of spectral data. The utility of the preparation and design of the above mentioned compounds has been shown to be clear in the results of their antimicrobial activity which revealed that some derivatives have potent activity exceeding or similar to the activity of the reference drugs.Conclusion:The insertion of triazole or thiazole moieties to be fused with quinazoline ring helps to enhance its antimicrobial activity.
- Subjects :
- Pharmacology
Azoles
Benzimidazole
Molecular Structure
010405 organic chemistry
Thiazepines
Triazole
General Medicine
Microbial Sensitivity Tests
010402 general chemistry
Antimicrobial
Ring (chemistry)
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
chemistry.chemical_compound
Structure-Activity Relationship
chemistry
Anti-Infective Agents
Drug Discovery
Quinazoline
Quinazolines
Thiazepine
Tetrazole
Thiazole
Subjects
Details
- ISSN :
- 18755607
- Volume :
- 20
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Mini reviews in medicinal chemistry
- Accession number :
- edsair.doi.dedup.....c701aefa504303cd69b74ab9e15c6e2c