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MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression
- Source :
- Cell Reports, Vol 16, Iss 10, Pp 2554-2564 (2016)
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- SummaryAberrant activation of Wnt/β-catenin signaling is a major driving force in colon cancer. Wnt/β-catenin signaling induces the expression of the transcription factor c-Myc, leading to cell proliferation and tumorigenesis. c-Myc regulates multiple biological processes through its ability to directly modulate gene expression. Here, we identify a direct target of c-Myc, termed MYU, and show that MYU is upregulated in most colon cancers and required for the tumorigenicity of colon cancer cells. Furthermore, we demonstrate that MYU associates with the RNA binding protein hnRNP-K to stabilize CDK6 expression and thereby promotes the G1-S transition of the cell cycle. These results suggest that the MYU/hnRNP-K/CDK6 pathway functions downstream of Wnt/c-Myc signaling and plays a critical role in the proliferation and tumorigenicity of colon cancer cells.
- Subjects :
- 0301 basic medicine
Carcinogenesis
Mice, Nude
Biology
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Heterogeneous-Nuclear Ribonucleoprotein K
Proto-Oncogene Proteins c-myc
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Cell Line, Tumor
Gene expression
medicine
Animals
Humans
lcsh:QH301-705.5
Wnt Signaling Pathway
Transcription factor
Cell Proliferation
Base Sequence
Cell growth
Cell Cycle
Wnt signaling pathway
Cyclin-Dependent Kinase 6
Cell cycle
Clone Cells
Up-Regulation
Cell biology
030104 developmental biology
lcsh:Biology (General)
030220 oncology & carcinogenesis
Colonic Neoplasms
biology.protein
RNA, Long Noncoding
Cyclin-dependent kinase 6
Subjects
Details
- ISSN :
- 22111247
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Cell Reports
- Accession number :
- edsair.doi.dedup.....c6edcb320f19dffc6629ca933595994a