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Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa
- Source :
- PLoS ONE, Vol 15, Iss 8, p e0237600 (2020), PLoS ONE
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- BackgroundPreeclampsia and eclampsia are common complications of pregnancy globally, including sub-Saharan African (SSA) countries. Although it has a high burden on maternal and neonatal mortality and morbidity, evidence on the risk of the problem is limited. Therefore, the aim of this review was to examine the factors associated with preeclampsia and eclampsia among mothers in SSA countries.MethodsWe searched article from SSA countries using electronic database MEDLINE, EMBASE, PubMed, CINAHL published in English from January 2000 to May 2020. Two reviewers independently screened, extracted and assessed the quality of the articles. Both random and fixed effect model were used for analysis. Heterogeneity of the studies and publication bias were checked. STATA 16 used for analysis.ResultsFifty-one studies met the inclusion criteria and included in this review. The following factors were identified through meta-analysis: being primiparous (OR: 2.52; 95% CI:1.19, 3.86), previous history of maternal preeclampsia/eclampsia (OR:5.6; 95% CI:1.82, 9.28), family history of preeclampsia/eclampsia (OR:1.68; 95% CI:1.26, 2.11), high maternal body mass index (OR: 1.69; 95% CI:1.17, 2.21), chronic hypertension (OR: 2.52; 95% CI:1.29, 3.74), anaemia during pregnancy (OR: 3.22; 95% CI:2.70, 3.75) and lack of antenatal care visits (OR: 2.71; 95% CI:1.45, 3.96). There was inconclusive evidence for a relationship with a number of other factors, such as nutrition and related factors, antenatal care visits, birth spacing, and other factors due to few studies found in our review.ConclusionsThe risk of preeclampsia and eclampsia is worse among women who have a history of preeclampsia/eclampsia (either themselves or family members), primiparous, obesity and overweight, living with chronic disease, having anaemia during pregnancy and absence from ANC visits. Therefore, investment must be made in women's health needs to reduce the problem and health service providers need to give due attention to high-risk women.
- Subjects :
- Epidemiology
Maternal Health
Blood Pressure
Overweight
Vascular Medicine
0302 clinical medicine
Mathematical and Statistical Techniques
Pre-Eclampsia
Pregnancy
Risk Factors
Medicine and Health Sciences
Eclampsia
030212 general & internal medicine
Family history
reproductive and urinary physiology
030219 obstetrics & reproductive medicine
Multidisciplinary
Obstetrics
Incidence
Statistics
Obstetrics and Gynecology
Anemia
Hematology
Metaanalysis
female genital diseases and pregnancy complications
Meta-analysis
Hypertension
Physical Sciences
Medicine
Female
medicine.symptom
Research Article
medicine.medical_specialty
Complications of pregnancy
Science
Research and Analysis Methods
Preeclampsia
03 medical and health sciences
Hypertensive Disorders in Pregnancy
Antenatal Care
medicine
Humans
Obesity
Statistical Methods
Africa South of the Sahara
business.industry
Publication bias
medicine.disease
Pregnancy Complications
Medical Risk Factors
Women's Health
business
Mathematics
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....c6d7bcc448559481e59d51d12bb6b8e8