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Interleukin-10 Polymorphisms in Spanish Patients With Ibd
- Source :
- Inflammatory Bowel Diseases. 11:739-743
- Publication Year :
- 2005
- Publisher :
- Oxford University Press (OUP), 2005.
-
Abstract
- Background: Inflammatory bowel disease (IBD) is considered a heterogeneous, complex polygenic disease where both genetic and environmental factors are involved in the development of the disease. Interleukin-10 (IL-10) is a regulatory cytokine that might play an important role in disease pathogenesis. IL-10 contains single nucleotide polymorphisms and 2 polymorphic microsatellites in the 5′-flanking region. Our aim was to ascertain if any of these polymorphic markers is associated with IBD among Spanish patients. Methods: We genotyped 470 patients with IBD, 242 with ulcerative colitis and 228 with Crohn's disease (CD), and 572 ethnically matched controls for microsatellites IL-10R and IL-10G and 2 single nucleotide polymorphisms at positions -1082 and -819 in the proximal promoter of the gene. Results: IL-10G14 microsatellite allele as well as -1082G allele were significantly increased in patients with CD. The combined presence of both alleles in 1 individual notably increased the risk to develop CD (P = 0.00006, odds ratio = 3.18). Conclusion: IL-10 polymorphisms contribute to susceptibility to CD in Spanish population.
- Subjects :
- Male
Molecular Sequence Data
Single-nucleotide polymorphism
Disease
Polymerase Chain Reaction
Severity of Illness Index
Inflammatory bowel disease
Cohort Studies
Crohn Disease
Reference Values
Odds Ratio
Humans
Immunology and Allergy
Medicine
Genetic Predisposition to Disease
Allele
Probability
Genetics
Crohn's disease
Polymorphism, Genetic
Base Sequence
business.industry
Incidence
Gastroenterology
Odds ratio
Inflammatory Bowel Diseases
medicine.disease
Ulcerative colitis
Interleukin-10
Spain
Genetic marker
Case-Control Studies
Immunology
Colitis, Ulcerative
Female
business
Microsatellite Repeats
Subjects
Details
- ISSN :
- 10780998
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Inflammatory Bowel Diseases
- Accession number :
- edsair.doi.dedup.....c6d3db882219e4cb11919a2b61d0cec8