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Strategic Anti-SARS-CoV-2 Serology Testing in a Low Prevalence Setting: The COVID-19 Contact (CoCo) Study in Healthcare Professionals
- Source :
- Infectious Diseases and Therapy, Vol 9, Iss 4, Pp 837-849 (2020), Infectious diseases and therapy, New Zealand, Infectious Diseases and Therapy
- Publication Year :
- 2020
- Publisher :
- Adis, Springer Healthcare, 2020.
-
Abstract
- Background Serology testing is explored for epidemiological research and to inform individuals after suspected infection. During the coronavirus disease 2019 (COVID-19) pandemic, frontline healthcare professionals (HCP) may be at particular risk for infection. No longitudinal data on functional seroconversion in HCP in regions with low COVID-19 prevalence and low pre-test probability exist. Methods In a large German university hospital, we performed weekly questionnaire assessments and anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) measurements with various commercial tests, a novel surrogate virus neutralisation test, and a neutralisation assay using live SARS-CoV-2. Results From baseline to week 6, 1080 screening measurements for anti-SARS CoV-2 (S1) IgG from 217 frontline HCP (65% female) were performed. Overall, 75.6% of HCP reported at least one symptom of respiratory infection. Self-perceived infection probability declined over time (from mean 20.1% at baseline to 12.4% in week 6, p
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
030106 microbiology
Infectious and parasitic diseases
RC109-216
medicine.disease_cause
Virus
Immunoglobulin G
Serology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Healthcare professionals
Epidemiology
medicine
Cumulative incidence
030212 general & internal medicine
Seroconversion
Original Research
Coronavirus
Serological testing
biology
Pandemic
business.industry
SARS-CoV-2
Respiratory infection
COVID-19
Humoral immunity
Infectious Diseases
biology.protein
business
Infection
Subjects
Details
- Language :
- English
- ISSN :
- 21936382 and 21938229
- Volume :
- 9
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Infectious Diseases and Therapy
- Accession number :
- edsair.doi.dedup.....c6cea60846514fadb19142fbfadc170b