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The distribution of HLA-A, -B, and -DRB1 alleles and haplotypes in inhabitants of Guizhou Province of China
- Source :
- Journal of Biomedical Research
- Publication Year :
- 2010
-
Abstract
- The present study was aimed to analyze the frequencies of human leukocyte antigen (HLA)-A, -B, and -DRB1 alleles and A-B-DRB1, A-B, A-DRB1 and B-DRB1 haplotypes in inhabitants of Guizhou province, China. All samples were typed in the HLA-A,-B, and -DRB1 loci using the polymerase chain reaction-reverse sequence specific oligonucleotide probe (PCR-rSSOP) method and HLA polymorphisms were analyzed. A total of 18 HLA-A, 31 HLA-B, and 13 HLA-DRB1 alleles were found in the Guizhou population. The first two frequent alleles in the HLA-A, -B, and -DRB1 loci were A*11(30.72%) and A*02(30.65%), B*40(16.27%) and B*46(16.27%), and DRB1*09(15.91%) and DRB1*15(13.51%), respectively. The most common haplotype was A*02-B*46-DRB1*09(5.59%) in A-B-DRB1, A*02-B*46(11.73%) in A-B, B*46-DRB1*09(7.49%) in B-DRB1, and A*02-DRB1*09(8.08%) in A-DRB1. Some haplotypes with strong linkage disequilibrium (LD) were found not only in the common haplotypes, such as A*33-B*58, B*30-DRB1*07, and B*33-DRB1*03, but also in the rare haplotypes, such as A*01-B*37, B*37-DRB1*10, and A*01-DRB1*10. Guizhou inhabitants shared some characteristics of the Southern Chinese population but also had their own unique features. Overall, HLA polymorphism in Guizhou population was more consistent with that of Chengdu population than that of other populations in China.
- Subjects :
- Genetics
musculoskeletal diseases
disequilibrium
Linkage disequilibrium
education.field_of_study
haplotype
Population
Haplotype
allele
General Medicine
Human leukocyte antigen
Biology
General Biochemistry, Genetics and Molecular Biology
HLA-A
Guizhou
Polymorphism (computer science)
immune system diseases
human leukocyte antigen
Allele
education
China
skin and connective tissue diseases
linkage
Research Paper
Subjects
Details
- ISSN :
- 16748301
- Volume :
- 25
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of biomedical research
- Accession number :
- edsair.doi.dedup.....c6c90717e3ed20c0668ba0ebebb10cfa