The Effect of Some Liver Enzyme Inhibitors on the Hepatic Inactivation of Erythropoietin in Mice

Summary. In a series of experiments with polycythaemic mice the influence of liver enzyme inhibitors on erythropoietin activity was studied. SKF 525-A was found to increase the half disappearance time of the activity of administered sheep erythropoietin. Both the administration of SKF-525-A and Disulfiram were found to increase the half disappearance time of endogenous erythropoietin activity. It is concluded that these compounds block the inactivation of erythropoietin in the liver. A model in which the action of such inhibitors on the disappearance of endogenous erythropoietin activity can be tested, is proposed.