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Chromatin remodeling and tissue-selective responses of nuclear hormone receptors
- Source :
- Biochemistry and Cell Biology. 80:343-351
- Publication Year :
- 2002
- Publisher :
- Canadian Science Publishing, 2002.
-
Abstract
- Chromatin structure of eukaryotic genes regulates gene expression by controlling the accessibility of regulatory factors. To overcome the inhibitory nature of chromatin, protein complexes that modify higher order chromatin organization and histoneDNA contacts are critical players in regulating transcription. For example, nuclear hormone receptors regulate transcription by interacting with ATP-dependent chromatin-remodeling complexes and coactivators, which include histone acetyltransferases and histone methylases that modify the basic residues of histones. A growing number of tissue-specific nuclear hormone receptor ligands, termed "selective modulators", owe their specificity, at least in part, to the differential recruitment of these chromatin-modifying coactivators. The molecular mechanisms by which these compounds modulate the functions of nuclear hormone receptors are discussed here.Key words: chromatin, BRG1, SWISNF, nuclear receptor, glucorticoid receptor, transcription, MMTV.
- Subjects :
- Cell Nucleus
Histone Acetyltransferases
Receptors, Steroid
biology
Chemistry
Receptors, Cytoplasmic and Nuclear
Cell Biology
Biochemistry
Chromatin
Chromatin remodeling
Cell biology
Cell nucleus
Histone
medicine.anatomical_structure
Nuclear receptor
Organ Specificity
Transcription (biology)
biology.protein
medicine
Humans
Signal transduction
Molecular Biology
Signal Transduction
Subjects
Details
- ISSN :
- 12086002 and 08298211
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Biochemistry and Cell Biology
- Accession number :
- edsair.doi.dedup.....c6b00a18b193e4b8c51183257c5facd0
- Full Text :
- https://doi.org/10.1139/o02-082