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Chromatin remodeling and tissue-selective responses of nuclear hormone receptors

Authors :
Pei-Wen Hsiao
Bonnie J. Deroo
Trevor K. Archer
Source :
Biochemistry and Cell Biology. 80:343-351
Publication Year :
2002
Publisher :
Canadian Science Publishing, 2002.

Abstract

Chromatin structure of eukaryotic genes regulates gene expression by controlling the accessibility of regulatory factors. To overcome the inhibitory nature of chromatin, protein complexes that modify higher order chromatin organization and histone–DNA contacts are critical players in regulating transcription. For example, nuclear hormone receptors regulate transcription by interacting with ATP-dependent chromatin-remodeling complexes and coactivators, which include histone acetyltransferases and histone methylases that modify the basic residues of histones. A growing number of tissue-specific nuclear hormone receptor ligands, termed "selective modulators", owe their specificity, at least in part, to the differential recruitment of these chromatin-modifying coactivators. The molecular mechanisms by which these compounds modulate the functions of nuclear hormone receptors are discussed here.Key words: chromatin, BRG1, SWI–SNF, nuclear receptor, glucorticoid receptor, transcription, MMTV.

Details

ISSN :
12086002 and 08298211
Volume :
80
Database :
OpenAIRE
Journal :
Biochemistry and Cell Biology
Accession number :
edsair.doi.dedup.....c6b00a18b193e4b8c51183257c5facd0
Full Text :
https://doi.org/10.1139/o02-082