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Fungi.guru: Comparative genomic and transcriptomic resource for the fungi kingdom
- Source :
- Computational and Structural Biotechnology Journal, Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 3788-3795 (2020)
- Publication Year :
- 2020
-
Abstract
- Graphical abstract<br />The fungi kingdom is composed of eukaryotic heterotrophs, which are responsible for balancing the ecosystem and play a major role as decomposers. They also produce a vast diversity of secondary metabolites, which have antibiotic or pharmacological properties. However, our lack of knowledge of gene function in fungi precludes us from tailoring them to our needs and tapping into their metabolic diversity. To help remedy this, we gathered genomic and gene expression data of 19 most widely-researched fungi to build an online tool, fungi.guru, which contains tools for cross-species identification of conserved pathways, functional gene modules, and gene families. We exemplify how our tool can elucidate the molecular function, biological process and cellular component of genes involved in various biological processes, by identifying a secondary metabolite pathway producing gliotoxin in Aspergillus fumigatus, the catabolic pathway of cellulose in Coprinopsis cinerea and the conserved DNA replication pathway in Fusarium graminearum and Pyricularia oryzae. The tool is available at www.fungi.guru.
- Subjects :
- Pyricularia
lcsh:Biotechnology
Biophysics
Expression
Computational biology
Secondary metabolite
Biochemistry
Database
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Structural Biology
lcsh:TP248.13-248.65
Genetics
medicine
Gene family
Gene
030304 developmental biology
ComputingMethodologies_COMPUTERGRAPHICS
0303 health sciences
Gliotoxin
biology
fungi
Fungi
Biological sciences [Science]
food and beverages
biology.organism_classification
Co-expression
Computer Science Applications
Coprinopsis cinerea
Metabolism
chemistry
030220 oncology & carcinogenesis
Identification (biology)
Gene function
Function (biology)
Biotechnology
medicine.drug
Research Article
Subjects
Details
- ISSN :
- 20010370
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Computational and structural biotechnology journal
- Accession number :
- edsair.doi.dedup.....c6af2bf934add3c0b5e63ba453006c51