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The prognostic value of cerebrospinal fluid characteristics in dogs without deep pain perception due to thoracolumbar disc herniation

Authors :
Orit Chai
Yael Chamisha
Merav H. Shamir
Sharon Kuzi
Mary M. Christopher
Yael Merbl
Itamar Aroch
I. Srugo
K. Rothwell
Tali Bdolah-Abram
Source :
Research in Veterinary Science. 100:189-196
Publication Year :
2015
Publisher :
Elsevier BV, 2015.

Abstract

Providing a pre-operative prognosis for dogs presented with absent deep pain perception (DPP) is extremely challenging, as the overall recovery rates widely vary. This study assesses the possible correlation between the severity of spinal cord injury and CSF cytology in 31 paraplegic dogs presented with absent DPP due to acute thoracolumbar intervertebral disc herniation (TL-IVDH). All dogs underwent surgical decompression immediately following diagnosis. CSF TNCC, macrophage percentage and macrophage to monocyte (MΦ:M) ratio were significantly higher in dogs that failed to regain DPP within 10 days post-operatively and in dogs that failed to regain ambulation at the end of the study period (P 0.05). MΦ:M of 0.73 and higher corresponded to a sensitivity of 54% and specificity of 100% for prediction of a negative long-term outcome. CSF TNCC, macrophage percentage and MΦ:M ratio effectively predicted regaining DPP and the long-term outcome in dogs that lost DPP due to acute TL-IVDH.

Details

ISSN :
00345288
Volume :
100
Database :
OpenAIRE
Journal :
Research in Veterinary Science
Accession number :
edsair.doi.dedup.....c6adecfac51e25935e15264193a3434b
Full Text :
https://doi.org/10.1016/j.rvsc.2015.03.017