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The balancing act of DNA repeat expansions
- Source :
- Current opinion in geneticsdevelopment. 23(3)
- Publication Year :
- 2013
-
Abstract
- Expansions of microsatellite DNA repeats contribute to the inheritance of nearly 30 developmental and neurological disorders. Significant progress has been made in elucidating the molecular mechanisms of repeat expansions using various model organisms and mammalian cell culture, and models implicating nearly all DNA transactions such as replication, repair, recombination, and transcription have been proposed. It is likely that different models of repeat expansions are not mutually exclusive and may explain repeat instability for different developmental stages and tissues. This review focuses on the contributions from studies in budding yeast toward unraveling the mechanisms and genetic control of repeat expansions, highlighting similarities and differences of replication models and describing a balancing act hypothesis to account for apparent discrepancies.
- Subjects :
- DNA Replication
DNA Repair
DNA repair
ved/biology.organism_classification_rank.species
Biology
Genome
Article
chemistry.chemical_compound
Genetics
Humans
Model organism
Recombination, Genetic
DNA Repeat Expansion
ved/biology
Genome, Human
DNA replication
Genetic Diseases, Inborn
DNA
chemistry
Evolutionary biology
Microsatellite
Human genome
Developmental Biology
Subjects
Details
- ISSN :
- 18790380
- Volume :
- 23
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Current opinion in geneticsdevelopment
- Accession number :
- edsair.doi.dedup.....c6a80ce6efb441d5b42b13533809f45a