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Cytotoxic Alangium alkaloids from Alangium longiflorum
- Source :
- Phytochemistry. 67:894-897
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Seven alkaloids ( 1 – 7 ) were isolated from the stem bark of Alangium longiflorum . Compound 1 , (−)-10- O -demethylisocephaeline, was isolated for the first time as a naturally occurring product from a plant source. All structures were elucidated by detailed spectroscopic analysis. Biological evaluation showed that 2 , 10- O -demethylcephaeline, exhibited potent cytotoxic activity against human lung carcinoma (A549) and breast adenocarcinoma (MCF-7) with ED 50 values of 0.013 and 0.062 μM, respectively. The stereoisomer 1 was less potent than 2 , and related compounds with different hydroxy/methoxy substitution patterns were also less potent or inactive. Thus, compound 2 merits attention as a cytotoxic lead for further study.
- Subjects :
- Lung Neoplasms
Stereochemistry
Breast Neoplasms
Plant Science
Horticulture
Pharmacognosy
Biochemistry
Alkaloids
Cell Line, Tumor
Tetrahydroisoquinolines
Humans
Alangium
Cytotoxicity
Molecular Biology
Alangiaceae
Molecular Structure
biology
Terpenes
Alkaloid
Stereoisomerism
Biological activity
General Medicine
biology.organism_classification
visual_art
Plant Bark
visual_art.visual_art_medium
Bark
Alangium longiflorum
Drug Screening Assays, Antitumor
Subjects
Details
- ISSN :
- 00319422
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Phytochemistry
- Accession number :
- edsair.doi.dedup.....c69ec4cf853383560a01d3bc699c466d