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Quality of Anticoagulation and Treatment Satisfaction in Patients with Non-Valvular Atrial Fibrillation Treated with Vitamin K Antagonist: Result from the KORean Atrial Fibrillation Investigation II
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2018
- Publisher :
- The Korean Academy of Medical Sciences, 2018.
-
Abstract
- Background Vitamin K antagonist (VKA) to prevent thromboembolism in non-valvular atrial fibrillation (NVAF) patients has limitations such as drug interaction. This study investigated the clinical characteristics of Korean patients treated with VKA for stroke prevention and assessed quality of VKA therapy and treatment satisfaction. Methods We conducted a multicenter, prospective, non-interventional study. Patients with CHADS2 ≥ 1 and treated with VKA (started within the last 3 months) were enrolled from April 2013 to March 2014. Demographic and clinical features including risk factors of stroke and VKA treatment information was collected at baseline. Treatment patterns and international normalized ratio (INR) level were evaluated during follow-up. Time in therapeutic range (TTR) > 60% indicated well-controlled INR. Treatment satisfaction on the VKA use was measured by Treatment Satisfaction Questionnaire for Medication (TSQM) after 3 months of follow-up. Results A total of 877 patients (age, 67; male, 60%) were enrolled and followed up for one year. More than half of patients (56%) had CHADS2 ≥ 2 and 83.6% had CHA2DS2-VASc ≥ 2. A total of 852 patients had one or more INR measurement during their follow-up period. Among those patients, 25.5% discontinued VKA treatment during follow-up. Of all patients, 626 patients (73%) had poor-controlled INR (TTR < 60%) measure. Patients' treatment satisfaction measured with TSQM was 55.6 in global satisfaction domain. Conclusion INR was poorly controlled in Korean NVAF patients treated with VKA. VKA users also showed low treatment satisfaction.<br />Graphical Abstract
- Subjects :
- Male
medicine.medical_specialty
Vitamin K
medicine.drug_class
Cardiovascular Disorders
Non valvular atrial fibrillation
Time in therapeutic range
Satisfaction
Kaplan-Meier Estimate
Personal Satisfaction
030204 cardiovascular system & hematology
INR Control
Treatment satisfaction
03 medical and health sciences
Anticoagulation
0302 clinical medicine
Surveys and Questionnaires
Internal medicine
Republic of Korea
Atrial Fibrillation
medicine
Humans
In patient
International Normalized Ratio
Prospective Studies
030212 general & internal medicine
Stroke
Aged
business.industry
Anticoagulants
Vitamin K Antagonist
Atrial fibrillation
General Medicine
Middle Aged
Vitamin K antagonist
medicine.disease
Stroke prevention
Female
Original Article
business
Subjects
Details
- Language :
- English
- ISSN :
- 15986357 and 10118934
- Volume :
- 33
- Issue :
- 49
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Medical Science
- Accession number :
- edsair.doi.dedup.....c69db4e7e7e3e8547f8f2efdcfaefcf6