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Effects of ticagrelor on the pharmacokinetics of rivaroxaban in rats
- Source :
- Pharmaceutical Biology, Vol 58, Iss 1, Pp 630-635 (2020), Pharmaceutical Biology, article-version (VoR) Version of Record
- Publication Year :
- 2020
- Publisher :
- Taylor & Francis Group, 2020.
-
Abstract
- Context Rivaroxaban and ticagrelor are two common drugs for the treatment of atrial fibrillation and acute coronary syndrome. However, the drug–drug interaction between them is still unknown. Objective To investigate the effects of ticagrelor on the pharmacokinetics of rivaroxaban in rats both in vivo and in vitro. Materials and methods A sensitive and reliable UPLC-MS/MS method was developed for the determination of rivaroxaban in rat plasma. Ten Sprague-Dawley rats were randomly divided into ticagrelor pre-treated group (10 mg/kg/day for 14 days) and control group. The pharmacokinetics of orally administered rivaroxaban (10 mg/kg, single dose) with or without ticagrelor pre-treatment was investigated with developed UPLC-MS/MS method. Additionally, Sprague-Dawley rat liver microsomes were also used to investigate the drug–drug interaction between these two drugs in vitro. Results The Cmax (221.34 ± 53.33 vs. 691.18 ± 238.31 ng/mL) and the AUC(0–t) (1060.97 ± 291.21 vs. 3483.03 ± 753.83 μg·h/L) of rivaroxaban increased significantly (p
- Subjects :
- Male
Acute coronary syndrome
Ticagrelor
Drug-drug interaction
Pharmaceutical Science
RM1-950
Pharmacology
030226 pharmacology & pharmacy
01 natural sciences
Rats, Sprague-Dawley
03 medical and health sciences
Rat liver microsomes
0302 clinical medicine
Pharmacokinetics
Rivaroxaban
Drug Discovery
Medicine
Animals
Drug Interactions
atrial fibrillation
drug–drug interaction
anticoagulation
business.industry
rat liver microsomes
Atrial fibrillation
General Medicine
medicine.disease
0104 chemical sciences
Rats
010404 medicinal & biomolecular chemistry
Complementary and alternative medicine
Microsomes, Liver
Molecular Medicine
Uplc ms ms
Therapeutics. Pharmacology
business
Platelet Aggregation Inhibitors
uplc-ms/ms
medicine.drug
Factor Xa Inhibitors
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 17445116 and 13880209
- Volume :
- 58
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Biology
- Accession number :
- edsair.doi.dedup.....c690d8af0bb753ba2ceec522c9ffc852