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Splanchnic and leg substrate exchange after ingestion of a natural mixed meal in humans
- Source :
- Diabetes. 48:958-966
- Publication Year :
- 1999
- Publisher :
- American Diabetes Association, 1999.
-
Abstract
- The disposal of a mixed meal was examined in 11 male subjects by multiple (splanchnic and femoral) catheterization combined with double-isotope technique (intravenous [2-3H]glucose plus oral U-[14C]starch). Glucose kinetics and organ substrate balance were measured basally and for 5 h after eating pizza (600 kcal) containing carbohydrates 75 g as starch, proteins 37 g, and lipids 17 g. The portal appearance of ingested carbohydrate was maximal (1.0 mmol/min) between 30 and 60 min after the meal and gradually declined thereafter, but was still incomplete at 300 min (0.46+/-0.08 mmol/min). The total amount of glucose absorbed by the gut over the 5 h of the study was 247+/-26 mmol (45+/-6 g), corresponding to 60+/-6% of the ingested starch. Net splanchnic glucose balance (-6.7+/-0.5 micromol x kg(-1) x min(-1), basal) rose by 250-300% between 30 and 60 min and then returned to baseline. Hepatic glucose production (HGP) was suppressed slightly and only tardily in response to meal ingestion (approximately 30% between 120 and 300 min). Splanchnic glucose uptake (3.7+/-0.6 micromol x kg(-1) x min(-1), basal) peaked to 9.8+/-2.0 micromol x kg(-1) x min(-1) (P30% of the ingested proteins to the systemic circulation; and 5) after meal ingestion, skeletal muscle takes up BCAA to replenish muscle protein stores.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Starch
Endocrinology, Diabetes and Metabolism
Glucose uptake
Fatty Acids, Nonesterified
Hepatic Veins
Biology
Catheterization
chemistry.chemical_compound
Internal medicine
Internal Medicine
medicine
Humans
Insulin
Ingestion
Lactic Acid
Splanchnic Circulation
Leg
Meal
Metabolism
Femoral Vein
Middle Aged
Carbohydrate
Diet
Femoral Artery
Kinetics
Glucose
Endocrinology
Postprandial
Intestinal Absorption
chemistry
Food
Splanchnic
Amino Acids, Branched-Chain
Subjects
Details
- ISSN :
- 1939327X and 00121797
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....c684e714afd06b1573b90ab199d6e66b