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Cyclometalated Iridium(III) Complexes as Mitochondria‐targeting Photosensitizers against Cisplatin‐resistant Cells †
- Source :
- Photochemistry and Photobiology. 98:85-91
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Four iridium (III) complexes Ir1-Ir4 were synthesized and characterized. Possessing high singlet oxygen production ability and specific mitochondria-localization, Ir1 was developed as a mitochondria-targeting photosensitizer. Ir1 exhibited strong phototoxicity against cancer cell line A549 and its corresponding cisplatin-resistant one A549R. In contrast, Ir1 showed low cytotoxicity toward normal cell HLF. This selectivity resulted from the different uptake amount. With 405 nm irradiation, Ir1 induced mitochondria-mediated cell death in A549R cells, achieving the overcome of drug-resistant.
- Subjects :
- Programmed cell death
chemistry.chemical_element
Antineoplastic Agents
Apoptosis
Mitochondrion
Iridium
010402 general chemistry
01 natural sciences
Biochemistry
chemistry.chemical_compound
Coordination Complexes
Cell Line, Tumor
Photosensitizer
Physical and Theoretical Chemistry
Cytotoxicity
Photosensitizing Agents
010405 organic chemistry
Singlet oxygen
General Medicine
Mitochondria
0104 chemical sciences
chemistry
Biophysics
Cisplatin
Reactive Oxygen Species
Selectivity
Phototoxicity
Subjects
Details
- ISSN :
- 17511097 and 00318655
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Photochemistry and Photobiology
- Accession number :
- edsair.doi.dedup.....c683028fb500910c409adb10320bc3c7
- Full Text :
- https://doi.org/10.1111/php.13404