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Cyclometalated Iridium(III) Complexes as Mitochondria‐targeting Photosensitizers against Cisplatin‐resistant Cells †

Authors :
Xinlin Lin
Ruilin Guan
Mingwei Lin
Hui Chao
Ying Zhou
Kai Xiong
Yu Chen
Jun-Feng Kou
Liang-Nian Ji
Source :
Photochemistry and Photobiology. 98:85-91
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

Four iridium (III) complexes Ir1-Ir4 were synthesized and characterized. Possessing high singlet oxygen production ability and specific mitochondria-localization, Ir1 was developed as a mitochondria-targeting photosensitizer. Ir1 exhibited strong phototoxicity against cancer cell line A549 and its corresponding cisplatin-resistant one A549R. In contrast, Ir1 showed low cytotoxicity toward normal cell HLF. This selectivity resulted from the different uptake amount. With 405 nm irradiation, Ir1 induced mitochondria-mediated cell death in A549R cells, achieving the overcome of drug-resistant.

Details

ISSN :
17511097 and 00318655
Volume :
98
Database :
OpenAIRE
Journal :
Photochemistry and Photobiology
Accession number :
edsair.doi.dedup.....c683028fb500910c409adb10320bc3c7
Full Text :
https://doi.org/10.1111/php.13404