Clinical Relevance of Profilin Sensitization Concerning Oral Allergy Syndrome in Birch Pollen Sensitized Patients

Catalina Högerle, Marion San Nicolo, Donata Gellrich, Katharina Eder, Moritz Gröger Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University Munich, München, GermanyCorrespondence: Catalina Högerle, Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maiximilians-Universität München, Marchioninistr. 15, München, D- 81377, Germany, Tel +49 89 4400 73892, Fax +49 89 4400 76892, Email catalina.hoegerle@med.uni-muenchen.dePurpose: Many plant food allergens contain homologs to the major birch allergen Bet v 1; therefore, the majority of patients with birch pollen allergy suffer from oral allergy syndrome. We studied the relevance of sensitization of Bet v 1 and co-sensitization with profilin concerning the clinical manifestations of an oral allergy syndrome.Patients and Methods: A total of 1119 patients with a positive skin prick test to birch and diagnostic for specific IgE to the allergen components Bet v 1 and profilin were analyzed retrospectively regarding complaints in the upper and lower airways, with demographic data as well as oral and gastrointestinal allergy symptoms.Results: Patients with simultaneous specific IgE to the allergen components Bet v 1 and profilin have to deal more often with an oral allergy syndrome and intestinal reactions. They also suffer more frequently and severely from rhinitis symptoms and show a higher tendency for asthma. No increased number of systemic reactions was seen.Conclusion: Patients with birch allergy recognizing both allergens have more probabilities of suffering from an oral allergy syndrome, and allergologists should be aware of this in order to give better advice to their patients.Keywords: oral allergy syndrome, clinical relevance of allergens, birch pollen sensitization, profilin co-sensitization, component resolved diagnostic