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Photodynamic therapy of vulvar and vaginal condyloma and intraepithelial neoplasia using topically applied 5-aminolevulinic acid
- Publication Year :
- 2002
-
Abstract
- BACKGROUND AND OBJECTIVES To determine the feasibility of photodynamic therapy (PDT) of vulvar and vaginal condyloma and intraepithelial neoplasia (VIN, VAIN) and to compare PDT results with conventional treatments. STUDY DESIGN/MATERIALS AND METHODS Thirty-eight patients with vulvar or vaginal intraepithelial neoplasia (VIN) grade II/III (n = 22) or condyloma (n = 16) had 10% 5-aminolevulinic acid (ALA)-gel applied topically. After 2-4 hours, 80-125 J/cm(2) laser light at a wavelength of 635 nm was applied. PDT was compared to conventional treatments for condyloma (CO(2) laser evaporation) and for VIN III (laser evaporation, surgical excision). RESULTS The complete clearance rate for condyloma treated by PDT was 66% and the rate for IN was 57% (as determined by biopsy). Of the neoplasia patients, none with hyperkeratotic VIN (n = 4) responded, and only one of four with increased pigmentation cleared. No scarring occurred, and postoperative discomfort lasted 4.9 +/- 3.4 days. Reduced disease-free survival (DFS) was associated with multifocal VIN (P = 0.02, OR 2.17, 95% CI 1.15-4.08), but DFS did not vary with treatment mode. CONCLUSIONS Although PDT is not equally efficacious for all subgroups, PDT for condyloma and intraepithelial neoplasia appears to be as effective as conventional treatments, but with shorter healing time and excellent cosmetic results.
- Subjects :
- Adult
medicine.medical_specialty
Vaginal Neoplasms
Adolescent
medicine.medical_treatment
Administration, Topical
Vaginal Diseases
340 Law
Photodynamic therapy
Dermatology
Vulva
2708 Dermatology
Vaginal disease
Biopsy
medicine
Humans
Vulvar Diseases
Aged
Intraepithelial neoplasia
Vaginal intraepithelial neoplasia
Photosensitizing Agents
medicine.diagnostic_test
Vulvar Neoplasms
business.industry
Aminolevulinic Acid
Middle Aged
medicine.disease
Vulvar intraepithelial neoplasia
10174 Clinic for Gynecology
Surgery
2746 Surgery
medicine.anatomical_structure
Photochemotherapy
Condylomata Acuminata
Female
Laser Therapy
business
Precancerous Conditions
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c67fbd43d5994867726759b603951468