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Diastereoselective formal total synthesis of (+/-)-triptolide via a novel cationic cyclization of 2-alkenyl-1,3-dithiolane
- Source :
- Chemical communications (Cambridge, England). 46(31)
- Publication Year :
- 2010
-
Abstract
- A concise and diastereoselective formal total synthesis of triptolide, a natural product with a wide range of biological properties, is described. The key reaction is an unprecedented 6-endo-Trig cationic cyclization of a 2-alkenyl-1,3-dithiolane precursor induced by TMSOTf as Lewis acid.
- Subjects :
- Natural product
Stereochemistry
Metals and Alloys
Cationic polymerization
Total synthesis
Stereoisomerism
General Chemistry
Triptolide
Phenanthrenes
Catalysis
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Dithiolane
chemistry.chemical_compound
chemistry
Cyclization
Heterocyclic Compounds
Biological property
Cations
Materials Chemistry
Ceramics and Composites
Epoxy Compounds
Lewis acids and bases
Diterpenes
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 46
- Issue :
- 31
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....c67b64c252ef8f65d507be0f0cf98735