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A chimeric mouse model to study immunopathogenesis of HCV infection
- Source :
- Methods in Molecular Biology ISBN: 9781493914524
- Publication Year :
- 2014
-
Abstract
- Several human hepatotropic pathogens including chronic hepatitis C virus (HCV) have narrow species restriction, thus hindering research and therapeutics development against these pathogens. Developing a rodent model that accurately recapitulates hepatotropic pathogens infection, human immune response, chronic hepatitis, and associated immunopathogenesis is essential for research and therapeutics development. Here, we describe the recently developed AFC8 humanized liver- and immune system-mouse model for studying chronic hepatitis C virus and associated human immune response, chronic hepatitis, and liver fibrosis.
- Subjects :
- Hepacivirus
Liver fibrosis
Mice, Transgenic
Virus
Article
Mice
Immune system
medicine
Animals
Humans
biology
Stem Cells
Rodent model
Hepatitis C
biology.organism_classification
medicine.disease
Hematopoietic Stem Cells
Virology
Liver regeneration
Liver Regeneration
Disease Models, Animal
Liver
Immunology
Stem cell
Stem Cell Transplantation
Subjects
Details
- ISBN :
- 978-1-4939-1452-4
- ISSN :
- 19406029
- ISBNs :
- 9781493914524
- Volume :
- 1213
- Database :
- OpenAIRE
- Journal :
- Methods in molecular biology (Clifton, N.J.)
- Accession number :
- edsair.doi.dedup.....c66e6538dddf2ffc11a2ccd6e8b338e8