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An aerosol challenge model of tuberculosis in Mauritian cynomolgus macaques
- Source :
- PLOS ONE, PLoS ONE, Vol 12, Iss 3, p e0171906 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science, 2017.
-
Abstract
- BACKGROUND:New interventions for tuberculosis are urgently needed. Non-human primate (NHP) models provide the most relevant pre-clinical models of human disease and play a critical role in vaccine development. Models utilising Asian cynomolgus macaque populations are well established but the restricted genetic diversity of the Mauritian cynomolgus macaques may be of added value. METHODS:Mauritian cynomolgus macaques were exposed to a range of doses of M. tuberculosis delivered by aerosol, and the outcome was assessed using clinical, imaging and pathology-based measures. RESULTS:All macaques developed characteristic clinical signs and disease features of tuberculosis (TB). Disease burden and the ability to control disease were dependent on exposure dose. Mauritian cynomolgus macaques showed less variation in pulmonary disease burden and total gross pathology scores within exposure dose groups than either Indian rhesus macaques or Chinese cynomolgus macaques. CONCLUSIONS:The genetic homogeneity of Mauritian cynomolgus macaques makes them a potentially useful model of human tuberculosis.
- Subjects :
- Bacterial Diseases
0301 basic medicine
Enzyme-Linked Immunospot Assay
Physiology
lcsh:Medicine
Disease
Monkeys
Kidney
Severity of Illness Index
Cynomolgus macaque
Diagnostic Radiology
0302 clinical medicine
Human disease
Immune Physiology
Medicine and Health Sciences
Public and Occupational Health
Primate
lcsh:Science
Lung
Mammals
Multidisciplinary
biology
Radiology and Imaging
Magnetic Resonance Imaging
Pulmonary Imaging
Actinobacteria
Infectious Diseases
Liver
Vertebrates
Physical Sciences
Radiography, Thoracic
Anatomy
Liver pathology
Macaque
Research Article
Primates
Tuberculosis
Materials by Structure
Imaging Techniques
Materials Science
Pulmonary disease
Research and Analysis Methods
Interferon-gamma
03 medical and health sciences
Diagnostic Medicine
biology.animal
Old World monkeys
medicine
Animals
Disease burden
Aerosols
Biology and life sciences
Bacteria
business.industry
lcsh:R
Organisms
Kidneys
Renal System
Mycobacterium tuberculosis
Tropical Diseases
medicine.disease
Macaca fascicularis
030104 developmental biology
Mixtures
Amniotes
Immunology
lcsh:Q
business
Spleen
030215 immunology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLOS ONE, PLoS ONE, Vol 12, Iss 3, p e0171906 (2017), PLoS ONE
- Accession number :
- edsair.doi.dedup.....c66a0b436746159edd17505d4f21ada3