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Synthesis and biological studies of new quinazolines with ether functions in position 2
- Source :
- ARKIVOC, Vol 2019, Iss 5, Pp 96-107 (2019), ARKIVOC-Online Journal of Organic Chemistry, ARKIVOC-Online Journal of Organic Chemistry, 2019, 2019 (5), pp.96-107. ⟨10.24820/ark.5550190.p010.859⟩, ARKIVOC-Online Journal of Organic Chemistry, Arkat USA Inc, 2019, 2019 (5), pp.96-107. ⟨10.24820/ark.5550190.p010.859⟩
- Publication Year :
- 2019
- Publisher :
- Arkat USA, Inc., 2019.
-
Abstract
- International audience; A series of new quinazolines linked to triazoles through an ether chain in position 2 has been designed and synthetized through a flexible route. Cytotoxicity assays on selected cancer cell lines and inhibition studies toward a panel of representative mammalian kinases have been performed on these molecules.
- Subjects :
- Biological studies
010405 organic chemistry
Kinase
Stereochemistry
Cytotoxicity
Organic Chemistry
Ether
Kinases
[CHIM.THER]Chemical Sciences/Medicinal Chemistry
Triazoles
010402 general chemistry
01 natural sciences
0104 chemical sciences
3. Good health
lcsh:QD241-441
chemistry.chemical_compound
chemistry
lcsh:Organic chemistry
Quinazolines
Molecule
Cancer cell lines
Subjects
Details
- Language :
- English
- ISSN :
- 15517012 and 15517004
- Volume :
- 2019
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- ARKIVOC
- Accession number :
- edsair.doi.dedup.....c669dbe05d4d44ce951eb7cda1d6a907
- Full Text :
- https://doi.org/10.24820/ark.5550190.p010.859⟩