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Molecular Mechanisms of Skeletal Muscle Hypertrophy
- Source :
- Journal of Neuromuscular Diseases
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and by mechanical signals mediating the effect of resistance exercise. Muscle growth during hypertrophy is controlled at the translational level, through the stimulation of protein synthesis, and at the transcriptional level, through the activation of ribosomal RNAs and muscle-specific genes. mTORC1 has a central role in the regulation of both protein synthesis and ribosomal biogenesis. Several transcription factors and co-activators, including MEF2, SRF, PGC-1α4, and YAP promote the growth of the myofibers. Satellite cell proliferation and fusion is involved in some but not all muscle hypertrophy models.
- Subjects :
- 0301 basic medicine
Mef2
Skeletal muscle
Review
mTORC1
Biology
ribosomal biogenesis
MEF2
mTOR
muscle hypertrophy
SRF
transcriptional control
translational control
Muscle hypertrophy
03 medical and health sciences
0302 clinical medicine
Transcriptional regulation
medicine
Humans
Muscle, Skeletal
Transcription factor
PI3K/AKT/mTOR pathway
Cell growth
Hypertrophy
Cell biology
030104 developmental biology
medicine.anatomical_structure
Neurology
Protein Biosynthesis
Neurology (clinical)
Neuroscience
030217 neurology & neurosurgery
Signal Transduction
Subjects
Details
- ISSN :
- 22143602 and 22143599
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Neuromuscular Diseases
- Accession number :
- edsair.doi.dedup.....c657eb526b581296198fdf09619c6b18