Time course transcriptome data analysis for in vitro modeling of dilated cardiomyopathy using patient-derived induced pluripotent stem cells

Background Induced pluripotent stem cells (iPSCs) derived from dilated cardiomyopathy (DCM) patients offer an unprecedented platform for in vitro disease modeling[1]. Time course transcriptome analysis on the differentiation process from iPSCs to beating cardiomyocytes will reveal the holistic dynamic gene expression landscapes and pinpoint molecular deficiencies in cardiogenesis for DCM patients.