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Maternal impairment of transposon regulation inDrosophila melanogasterby mutations in the genesaubergine,piwiandSuppressor of variegation 205
- Source :
- Genetics Research. 92:261-272
- Publication Year :
- 2010
- Publisher :
- Hindawi Limited, 2010.
-
Abstract
- SummaryTP5, aPelement inserted in the telomere-associated sequences of the X chromosome, represses the excision of otherPelements in the germ line through a combination of maternal and zygotic effects. The maternal component of this repression is impaired by heterozygous mutations in theaubergineandSuppressor of variegation 205genes; one mutation in thepiwigene also appears to impair repression. In the female germ line, the level ofTP5mRNA is increased by these impairing mutations. The impairingaubergineandpiwimutations also increase the level of germ-line mRNA fromCP, a transgene that encodes theP-element transposase; however, theSuppressor of variegation 205mutation does not. These findings are discussed in terms of a model ofP-element regulation that involves post-transcriptional and chromatin re-organizing events mediated by maternally transmitted small RNAs derived from the telomericPelement.
- Subjects :
- Male
Transposable element
X Chromosome
Chromosomal Proteins, Non-Histone
Transposases
Piwi-interacting RNA
Genes, Insect
medicine.disease_cause
P element
Peptide Initiation Factors
Genetics
medicine
Animals
Drosophila Proteins
RNA-Induced Silencing Complex
Psychological repression
Transposase
Variegation
Mutation
biology
Egg Proteins
Gene Expression Regulation, Developmental
General Medicine
Telomere
biology.organism_classification
Drosophila melanogaster
Germ Cells
Chromobox Protein Homolog 5
Argonaute Proteins
DNA Transposable Elements
Female
Subjects
Details
- ISSN :
- 14695073 and 00166723
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Genetics Research
- Accession number :
- edsair.doi.dedup.....c64a57cdfa5628e67ff244ead73d49a5
- Full Text :
- https://doi.org/10.1017/s0016672310000352