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Maternal impairment of transposon regulation inDrosophila melanogasterby mutations in the genesaubergine,piwiandSuppressor of variegation 205

Authors :
Eric W. Cross
Michael J. Simmons
Michael W. Thorp
Erika L. Bjorklund
Jared T. Buschette
Katherine Peterson
Source :
Genetics Research. 92:261-272
Publication Year :
2010
Publisher :
Hindawi Limited, 2010.

Abstract

SummaryTP5, aPelement inserted in the telomere-associated sequences of the X chromosome, represses the excision of otherPelements in the germ line through a combination of maternal and zygotic effects. The maternal component of this repression is impaired by heterozygous mutations in theaubergineandSuppressor of variegation 205genes; one mutation in thepiwigene also appears to impair repression. In the female germ line, the level ofTP5mRNA is increased by these impairing mutations. The impairingaubergineandpiwimutations also increase the level of germ-line mRNA fromCP, a transgene that encodes theP-element transposase; however, theSuppressor of variegation 205mutation does not. These findings are discussed in terms of a model ofP-element regulation that involves post-transcriptional and chromatin re-organizing events mediated by maternally transmitted small RNAs derived from the telomericPelement.

Details

ISSN :
14695073 and 00166723
Volume :
92
Database :
OpenAIRE
Journal :
Genetics Research
Accession number :
edsair.doi.dedup.....c64a57cdfa5628e67ff244ead73d49a5
Full Text :
https://doi.org/10.1017/s0016672310000352