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Rituximab in refractory chronic inflammatory demyelinating polyneuropathy
- Source :
- MusclenerveREFERENCES. 61(5)
- Publication Year :
- 2019
-
Abstract
- Introduction Chronic inflammatory demyelinating polyneuropathy (CIDP) is a disorder in which early effective treatment is important to minimize disability from axonal degeneration. It has been suggested that some patients with CIDP may benefit from rituximab therapy, but there is no definitive evidence for this. Methods Baseline and post-rituximab-therapy neuromuscular Medical Research Council (MRC) sum scores, Inflammatory Neuropathy Cause and Treatment (INCAT) disability score, and functional status were assessed in 11 patients with refactory CIDP. Results The MRC sum score, INCAT disability score, and functional status improved in all patients after rituximab therapy. Discussion Our study provides evidence of the efficacy of rituximab therapy in at least some patients with CIDP. A placebo-controlled study to assess the effectiveness of rituximab therapy in CIDP with and without nodal antibodies is required to identify disease markers that predict responsiveness.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Physiology
Foot Orthoses
Chronic inflammatory demyelinating polyneuropathy
030105 genetics & heredity
Quadriplegia
Walkers
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Refractory
Rituximab therapy
Physiology (medical)
Internal medicine
Azathioprine
medicine
Effective treatment
Humans
Immunologic Factors
Treatment Failure
Disease markers
Mobility Limitation
Cyclophosphamide
Glucocorticoids
Aged
Plasma Exchange
business.industry
Immunoglobulins, Intravenous
Middle Aged
Mycophenolic Acid
medicine.disease
Treatment Outcome
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Functional status
Rituximab
Canes
Female
Neurology (clinical)
business
Axonal degeneration
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 10974598
- Volume :
- 61
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- MusclenerveREFERENCES
- Accession number :
- edsair.doi.dedup.....c63a688ff97cdccfd96d6e4ea773c8db