Sodium arsenite but not aluminum chloride stimulates ABC transporter activity in renal proximal tubules of killifish (Fundulus heteroclitus)

Authors :: Goezde Oezen
Eva-Maria Schentarra
Jan Stephan Bolten
Joerg Huwyler
Gert Fricker
Source :: Aquatic Toxicology. 252:106314
Publication Year :: 2022
Publisher :: Elsevier BV, 2022.
Abstract: ABC export proteins including Multidrug resistance-related protein 2 (Mrp2) serve as detoxification mechanism in renal proximal tubules due to active transport of xenobiotics and metabolic waste products into primary urine. The environmental pollutants aluminum and arsenic interfere with a multitude of regulatory mechanisms in the body and here their impact on ABC transporter function was studied. NaAsO

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