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Effects of sea buckthorn (Hippophaë rhamnoides) juice and L-quebrachitol on type 2 diabetes mellitus in db/db mice
- Source :
- Journal of Functional Foods, Vol 16, Iss, Pp 223-233 (2015)
- Publication Year :
- 2015
- Publisher :
- Elsevier, 2015.
-
Abstract
- To study the effects of sea buckthorn juice and L-quebrachitol on type 2 diabetes, db/db mice were given 10-week gavage administration of pure sea buckthorn juice or sea buckthorn juice enriched with L-quebrachitol. Treatment with sea buckthorn juice reduced the feed intake, body weight gain, random blood glucose level, and the expression of insulin receptor β in the liver. Sea buckthorn juice significantly improved glucose tolerance and the integrity of pancreatic tissue. Administration of sea buckthorn juice enriched in L-quebrachitol increased fasting insulin level in plasma and showed similar effects on random blood glucose level, glucose tolerance and the pancreatic tissue as observed for pure sea buckthorn juice. The results suggest hypoglycaemic effects of sea buckthorn juice in type 2 diabetic db/db mice, likely associated with improvement of pancreas and reversal of insulin resistance. L-quebrachitol present in sea buckthorn might have contributed to the effects observed.
- Subjects :
- Insulin receptor β
medicine.medical_specialty
Medicine (miscellaneous)
Type 2 diabetes
chemistry.chemical_compound
Insulin resistance
Internal medicine
Type 2 diabetes mellitus
medicine
TX341-641
Food science
Quebrachitol
ta116
Db/db mouse
Nutrition and Dietetics
biology
business.industry
Nutrition. Foods and food supply
Type 2 Diabetes Mellitus
Hippophae rhamnoides
Glucose tolerance
medicine.disease
biology.organism_classification
L-quebrachitol
Insulin receptor
Db/db Mouse
Endocrinology
medicine.anatomical_structure
chemistry
Sea buckthorn
biology.protein
Pancreas
business
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....c626a37989d0beb9fcfb5cbcb34b4bdf