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Evaluation of patients diagnosed with essential arterial hypertension through network analysis
- Source :
- Irish Journal of Medical Science (1971 -). 185:443-451
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Essential hypertension is a chronic pathology that causes long-term complications due to late diagnosis of patients, the inability to control the disease through medication, or due to the complexity of associated risk factors. Our study sets out to identify specific patterns of response to arterial hypertension treatment, by taking into consideration the multiple connections between risk factors in a relevant population of hypertensive patients. Network science is an emerging paradigm, branching over multiple aspects of physical, biological and social phenomena. One such branch, which has brought significant contributions to medical science, is the field of network medicine. To apply this methodology, we create a complex network of hypertensive patients based on their common medical conditions. Consequently, we obtain a community-based representation which pinpoints specific—and previously uncharted—patterns of hypertension development. This approach creates incentives for evaluating patient’s treatment efficacy, by considering its network topological position. Distinct clusters of patients with common properties have emerged for each study group (group A—treated with nebivolol, group B—treated with perindopril and group C—treated with candesartan cilexetil). Therefore, our network-based clustering allows for a better treatment assessment.
- Subjects :
- Adult
Male
0301 basic medicine
Network medicine
medicine.medical_specialty
Population
Tetrazoles
Blood Pressure
Network science
Disease
030204 cardiovascular system & hematology
Essential hypertension
Nebivolol
03 medical and health sciences
0302 clinical medicine
Perindopril
medicine
Humans
Prospective Studies
Intensive care medicine
education
Antihypertensive Agents
Aged
education.field_of_study
business.industry
Biphenyl Compounds
General Medicine
Middle Aged
medicine.disease
Biphenyl compound
030104 developmental biology
Blood pressure
Hypertension
Physical therapy
Benzimidazoles
Female
Essential Hypertension
business
medicine.drug
Subjects
Details
- ISSN :
- 18634362 and 00211265
- Volume :
- 185
- Database :
- OpenAIRE
- Journal :
- Irish Journal of Medical Science (1971 -)
- Accession number :
- edsair.doi.dedup.....c61e0b1f8f3eb78b6ed66d31da6a096f