Imatinib sensitizes CLL lymphocytes to chlorambucil

Authors :: Lawrence Panasci
Moulay A. Alaoui-Jamali
Loignon M
Zhiyuan Xu
Grzywacz K
Raquel Aloyz
Source :: Leukemia. 18:409-414
Publication Year :: 2003
Publisher :: Springer Science and Business Media LLC, 2003.
Abstract: The effect of imatinib on chlorambucil (CLB) cytotoxicity in chronic lymphocytic leukemia (CLL) lymphocytes was examined in vitro. Imatinib sensitizes the WSU and I83 human CLL cell lines, 10- and two-fold, respectively, to CLB. Furthermore, in primary cultures of malignant B-lymphocytes obtained from 12 patients with CLL (seven patients were untreated and five treated with CLB), imatinib synergistically sensitized these lymphocytes from two- to 20-fold to CLB. This synergistic effect was observed at concentrations of imatinib (