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Multiplexed Representation of Itch and Pain and Their Interaction in the Primary Somatosensory Cortex

Authors :
Seunghui, Woo
Yoo Rim, Kim
Myeong Seong, Bak
Geehoon, Chung
Sang Jeong, Kim
Sun Kwang, Kim
Source :
Experimental Neurobiology. 31:324-331
Publication Year :
2022
Publisher :
The Korean Society for Brain and Neural Science, 2022.

Abstract

Itch and pain are distinct sensations that share anatomically similar pathways: from the periphery to the brain. Over the last decades, several itch-specific neural pathways and molecular markers have been identified at the peripheral and spinal cord levels. Although the perception of sensation is ultimately generated at the brain level, how the brain separately processes the signals is unclear. The primary somatosensory cortex (S1) plays a crucial role in the perception of somatosensory information, including touch, itch, and pain. In this study, we investigated how S1 neurons represent itch and pain differently. First, we established a spontaneous itch and pain mouse model. Spontaneous itch or pain was induced by intradermal treatment with 5-HT or capsaicin on the lateral neck and confirmed by a selective increase in scratching or wiping-like behavior, respectively. Next

Details

ISSN :
20938144 and 12262560
Volume :
31
Database :
OpenAIRE
Journal :
Experimental Neurobiology
Accession number :
edsair.doi.dedup.....c61091e2c7f6a0dc81eeb2764a9a7ba6
Full Text :
https://doi.org/10.5607/en22029