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The effect of gender in clinically isolated syndrome (CIS): a meta-analysis
- Source :
- Multiple sclerosis (Houndmills, Basingstoke, England). 18(5)
- Publication Year :
- 2011
-
Abstract
- Background/Objective: A clinically isolated syndrome compatible with demyelination (CIS) is the initial presentation for the majority of people that go on to develop multiple sclerosis (MS). There has previously been little work examining the effect of gender on the development and progression of CIS. Methods: Data from observational studies of CIS were used. In total, 33 suitable studies with 4732 subjects were identified. Results: The overall relative risk (RR) of CIS in females compared with males was 2.12 (95% CI 1.94–2.32). The RR of females developing MS following CIS was 1.20 (95% CI 0.98–1.46) compared with males. Conclusions: These data imply that the gender bias seen in MS is caused by factors acting early in the disease process.
- Subjects :
- Male
medicine.medical_specialty
Multiple Sclerosis
Time Factors
Risk Assessment
Sex Factors
Risk Factors
Internal medicine
Odds Ratio
Medicine
Humans
Optic neuritis
Clinically isolated syndrome
Chi-Square Distribution
business.industry
Multiple sclerosis
Odds ratio
medicine.disease
Prognosis
Neurology
Meta-analysis
Relative risk
Immunology
Disease Progression
Observational study
Female
Neurology (clinical)
business
Chi-squared distribution
Demyelinating Diseases
Subjects
Details
- ISSN :
- 14770970
- Volume :
- 18
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Multiple sclerosis (Houndmills, Basingstoke, England)
- Accession number :
- edsair.doi.dedup.....c61052ed8233ed1337a656ba155f837a