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Pharmacokinetics of cefpirome administered intravenously or intramuscularly to rats and dogs
- Source :
- Journal of Antimicrobial Chemotherapy. 29:31-37
- Publication Year :
- 1992
- Publisher :
- Oxford University Press (OUP), 1992.
-
Abstract
- The pharmacokinetic profile of cefpirome was evaluated in rats and dogs after a single intravenous or intramuscular dose. A two-compartment open model was used for the calculation of the pharmacokinetic parameters for both routes of administration. The elimination half-lives after intravenous and intramuscular administration of 20 mg/kg cefpirome did not differ significantly and ranged from 0.4 h in rats to 1.1 h in dogs. Cefpirome was mainly excreted via the kidneys. After iv or im dosing of the compound, between 80% (dogs) and 90% (rats) was recovered in urine within 24 h. The bioavailability of cefpirome in rats and dogs after both routes of administration was almost identical when calculated either by the AUC or the urinary recovery rates.
- Subjects :
- Male
Microbiology (medical)
medicine.drug_class
Urinary system
Antibiotics
Biological Availability
Urine
Pharmacology
Injections, Intramuscular
Dogs
Pharmacokinetics
medicine
Animals
Pharmacology (medical)
Dosing
Dose-Response Relationship, Drug
business.industry
Half-life
Rats, Inbred Strains
Cefpirome
Cephalosporins
Rats
Bioavailability
Infectious Diseases
Injections, Intravenous
business
medicine.drug
Subjects
Details
- ISSN :
- 14602091 and 03057453
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Journal of Antimicrobial Chemotherapy
- Accession number :
- edsair.doi.dedup.....c5fd04913ee27b2b2527f019da6680ae