Sensitive Detection of SARS-CoV-2–Specific Antibodies in Dried Blood Spot Samples

Authors :: Matthew K. O'Shea
Stephen Taylor
Marisol Perez-Toledo
Gabriella L. Morley
Margaret Goodall
Sian E Jossi
Adam F. Cunningham
Sian E Faustini
Alex G. Richter
Adrian M Shields
Edith Marcial-Juarez
Maddy L. Newby
Yasunori Watanabe
Joel D. Allen
Mark T. Drayson
Max Crispin
Source :: Emerging Infectious Diseases, Vol 26, Iss 12, Pp 2970-2973 (2020), Emerging Infectious Diseases
Publication Year :: 2020
Publisher :: Centers for Disease Control and Prevention, 2020.
Abstract: Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.

Subjects :: Microbiology (medical)
2019-20 coronavirus outbreak
Epidemiology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
030231 tropical medicine
DBS
lcsh:Medicine
Antibodies, Viral
medicine.disease_cause
COVID-19 Serological Testing
Serology
lcsh:Infectious and parasitic diseases
03 medical and health sciences
respiratory infections
0302 clinical medicine
Predictive Value of Tests
antibody
medicine
Humans
viruses
lcsh:RC109-216
030212 general & internal medicine
Coronavirus
biology
business.industry
SARS-CoV-2
lcsh:R
Dispatch
COVID-19
Serum samples
dried blood spot
Virology
zoonoses
Dried blood spot
nervous system diseases
Sensitive Detection of SARS-CoV-2–Specific Antibodies in Dried Blood Spot Samples
Specific antibody
Infectious Diseases
surgical procedures, operative
nervous system
coronavirus disease
Case-Control Studies
Spike Glycoprotein, Coronavirus
biology.protein
Dried Blood Spot Testing
Antibody
business
therapeutics
severe acute respiratory syndrome coronavirus 2

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