Back to Search
Start Over
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: Insights from an analysis of 500 cases
- Source :
- Clinical Immunology. 203:1-8
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Background: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry. Methods: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed. Results: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08–9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81–31.67], p < 0.0001). Conclusions: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.
- Subjects :
- Adult
Male
0301 basic medicine
Adolescent
medicine.medical_treatment
Giant Cell Arteritis
Immunology
Connective tissue
Autoimmune Diseases
Young Adult
03 medical and health sciences
0302 clinical medicine
Immune system
Adjuvants, Immunologic
Humans
Immunology and Allergy
Medicine
Hepatitis B Vaccines
Autoinflammatory disease
Israel
Child
Connective Tissue Diseases
Autoimmune/inflammatory syndrome induced by adjuvants
Aged
Aged, 80 and over
Inflammation
business.industry
Vaccination
Infant, Newborn
Infant
Syndrome
Middle Aged
030104 developmental biology
medicine.anatomical_structure
Influenza Vaccines
Child, Preschool
Female
business
Mixed pattern
Adjuvant
Autoinflammatory Disorders
030215 immunology
Subjects
Details
- ISSN :
- 15216616
- Volume :
- 203
- Database :
- OpenAIRE
- Journal :
- Clinical Immunology
- Accession number :
- edsair.doi.dedup.....c5e447cb80b7f2eabb37464ddd3072e7